Excessive Daytime Somnolence and Increased Rapid Eye Movement Pressure in Myotonic Dystrophy
نویسندگان
چکیده
منابع مشابه
Modafinil reduces excessive somnolence and enhances mood in patients with myotonic dystrophy.
OBJECTIVE To evaluate the potential of modafinil in reducing excessive daytime somnolence (EDS) and enhancing indexes of quality of life and mood in patients with myotonic dystrophy (DM). METHODS Forty patients with DM were randomized to receive modafinil and placebo for 14 days each, using a double-blind, cross-over design. Before and after each trial, subjects completed handgrip strength te...
متن کاملMultimodal Evoked Potential and Eye Movement Abnormalities in Myotonic Dystrophy
By means of multimodal evoked potentials (EPs) we evaluated the central nervous system (CNS) involvement in 25 subjects suffering from myotonic dystrophy (MD): brainstem auditory evoked potentials (BAEPs), middle-latency auditory evoked potentials (MLAEPs) and somatosensory evoked potentials (SEPs) from upper limb were performed on all the subject, whereas only the 19 patients, whose clinical o...
متن کاملSnoring and excessive daytime somnolence among Polish middle-aged adults.
There is considerable interest in the association of snoring and health consequences that have been linked to more severe sleep-disordered breathing, including obstructive sleep apnoea syndrome. The goal of this investigation was to assess the independent association of heavy, habitual snoring and daytime sleepiness. For this, a cross-sectional, population based study of snoring, sleepiness and...
متن کاملEye movements in myotonic dystrophy
Fixation and pursuit movements, movements of regard, of convergence and divergence, and ocular reaction time were recorded electrooculographically in 10 patients with myotonic dystrophy. With the exception of pursuit movements, normal responses xoere present in 9 out of 10 patients. All of the patients demonstrated a selective and pronounced impairment of pursuit movements which xoere elicited ...
متن کاملDecreased hypocretin-1 (Orexin-A) levels in the cerebrospinal fluid of patients with myotonic dystrophy and excessive daytime sleepiness.
STUDY OBJECTIVE Myotonic dystrophy type 1 is a multisystem disorder with myotonia, muscle weakness, cataracts, endocrine dysfunction, and intellectual impairment. This disorder is caused by a CTG triplet expansion in the 3' untranslated region of the DMPK gene on 19q13. Myotonic dystrophy type 1 is frequently associated with excessive daytime sleepiness, sharing with narcolepsy a short sleep la...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Sleep
سال: 2002
ISSN: 1550-9109,0161-8105
DOI: 10.1093/sleep/25.6.662